Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils

Abstract Background Mice are susceptible to infections with the rodent filarial nematode Litomosoides sigmodontis and develop immune responses that resemble those of human filarial infections. Thus, the L. sigmodontis model is used to study filarial immunomodulation, protective immune responses agai...

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Bibliographic Details
Main Authors: Stefan J. Frohberger, Jesuthas Ajendra, Jayagopi Surendar, Wiebke Stamminger, Alexandra Ehrens, Benedikt C. Buerfent, Katrin Gentil, Achim Hoerauf, Marc P. Hübner
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Parasites & Vectors
Subjects:
Litomosoides sigmodontis
Filariae
Eosinophil
IL-4
IL-5
Microfilaria
Online Access:http://link.springer.com/article/10.1186/s13071-019-3502-z

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http://link.springer.com/article/10.1186/s13071-019-3502-z

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