Neuroprotective effects of Alda-1 mitigate spinal cord injury in mice: involvement of Alda-1-induced ALDH2 activation-mediated suppression of reactive aldehyde mechanisms

Neuroprotective effects of Alda-1 mitigate spinal cord injury in mice: involvement of Alda-1-induced ALDH2 activation-mediated suppression of reactive aldehyde mechanisms

Spinal cord injury (SCI) is associated with high production and excessive accumulation of pathological 4-hydroxy-trans-2-nonenal (4-HNE), a reactive aldehyde, formed by SCI-induced metabolic dysregulation of membrane lipids. Reactive aldehyde load causes redox alteration, neuroinflammation, neurodeg...

Full description

Bibliographic Details
Main Authors: Mushfiquddin Khan, Fei Qiao, Pavan Kumar, S M Touhidul Islam, Avtar K Singh, Jeseong Won, Inderjit Singh
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Neural Regeneration Research
Subjects:
4-hydroxy-trans-2-nonenal; alda-1; aldh2; basso mouse scale score; functional recovery; mitochondrial function; neuroinflammation; neuroprotection; pain; spinal cord injury
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=1;spage=185;epage=193;aulast=Khan

Internet

http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=1;spage=185;epage=193;aulast=Khan

Similar Items