GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator

GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator

Abstract Cyclic phosphatidic acid (cPA) is a lipid mediator, which regulates adipogenic differentiation and glucose homeostasis by suppressing nuclear peroxisome proliferator-activated receptor γ (PPARγ). Glycerophosphodiesterase 7 (GDE7) is a Ca2+-dependent lysophospholipase D that localizes in the...

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Main Authors: Keisuke Kitakaze, Hanif Ali, Raiki Kimoto, Yasuhiro Takenouchi, Hironobu Ishimaru, Atsushi Yamashita, Natsuo Ueda, Tamotsu Tanaka, Yasuo Okamoto, Kazuhito Tsuboi
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04900-4

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https://doi.org/10.1038/s42003-023-04900-4

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