Hyperglycemia exerts disruptive effects on the secretion of TGF-β1 and its matrix ligands, decorin and biglycan, by mesenchymal sub-populations and macrophages during bone repair

Hyperglycemia exerts disruptive effects on the secretion of TGF-β1 and its matrix ligands, decorin and biglycan, by mesenchymal sub-populations and macrophages during bone repair

IntroductionBone has a high capacity for repair, but for patients with uncontrolled type 2 diabetes mellitus (T2DM), the associated hyperglycemia can significantly delay osteogenic processes. These patients respond poorly to fracture repair and bone grafts, leading to lengthy care plans due to arisi...

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Bibliographic Details
Main Authors: Norhayati Yusop, Ryan Moseley, Rachel J. Waddington
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Dental Medicine
Subjects:
mesenchymal stromal cells
bone repair
osteoblasts
macrophages
hyperglycemia
type 2 diabetes mellitus
Online Access:https://www.frontiersin.org/articles/10.3389/fdmed.2023.1200122/full

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https://www.frontiersin.org/articles/10.3389/fdmed.2023.1200122/full

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