Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome

Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome

Down Syndrome (DS), trisomy 21, is characterized by synaptic abnormalities and cognitive deficits throughout the lifespan and with development of Alzheimer's disease (AD) neuropathology and progressive cognitive decline in adults. Synaptic abnormalities are also present in the Ts65Dn mouse mode...

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Bibliographic Details
Main Authors: R.L. Nosheny, P.V. Belichenko, B.L. Busse, A.M. Weissmiller, V. Dang, D. Das, A. Fahimi, A. Salehi, S.J. Smith, W.C. Mobley
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Neurobiology of Disease
Subjects:
Down Syndrome
Ts65Dn mice
Synapses
BDNF
TrkB
Signaling endosomes
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115000571

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http://www.sciencedirect.com/science/article/pii/S0969996115000571

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