Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease

Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease

<p>Abstract</p> <p>Background</p> <p>Several recent studies have shown that angiotensin type 1 receptor (AT1) antagonists such as candesartan inhibit the microglial inflammatory response and dopaminergic cell loss in animal models of Parkinson's disease. However, t...

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Bibliographic Details
Main Authors: Garrido-Gil Pablo, Joglar Belen, Rodriguez-Perez Ana I, Guerra Maria J, Labandeira-Garcia Jose L
Format: Article
Language:English
Published: BMC 2012-02-01
Series:Journal of Neuroinflammation
Subjects:
Angiotensin
AT1
neuroinflammation
neuroprotection
microglia
Parkinson
peroxisome proliferator-activated receptor gamma
telmisartan
Online Access:http://www.jneuroinflammation.com/content/9/1/38

Internet

http://www.jneuroinflammation.com/content/9/1/38

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