DUBs, new members in the hypoxia signaling clUb
Cellular protein homeostasis is tightly regulated by ubiquitination. Responsible for target protein ubiquitination is a class of enzymes, the so-called ubiquitin (Ub) E3-ligases. They are opposed to a second class of enzymes, called DeUBiquitinating enzymes (DUBs), which can remove polyubiquitin cha...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00053/full |
| _version_ | 1818023790219624448 |
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| author | Amelie S Schober Amelie S Schober Edurne eBerra |
| author_facet | Amelie S Schober Amelie S Schober Edurne eBerra |
| author_sort | Amelie S Schober |
| collection | DOAJ |
| description | Cellular protein homeostasis is tightly regulated by ubiquitination. Responsible for target protein ubiquitination is a class of enzymes, the so-called ubiquitin (Ub) E3-ligases. They are opposed to a second class of enzymes, called DeUBiquitinating enzymes (DUBs), which can remove polyubiquitin chains from their specific target proteins. The coaction of the two sets of enzymes allow the cell to adapt its overall protein content and the abundance of particular proteins to a variety of cellular and environmental stresses, including hypoxia. In recent years, DUBs have been highlighted to play major roles in many diseases, including cancer, both as tumor suppressors and oncogenes. Therefore, DUBs are emerging as promising targets for cancer-cell specific treatment. Here, we will review the current understanding of DUBs implicated in the control of hypoxia-inducible factor (HIF), the regulation of DUBs by hypoxia and the use of DUB-specific drugs to target tumor hypoxia signaling. |
| first_indexed | 2024-12-10T03:49:55Z |
| format | Article |
| id | doaj.art-26399f05c77a46a1989ec5b365d90f5a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T03:49:55Z |
| publishDate | 2016-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-26399f05c77a46a1989ec5b365d90f5a2022-12-22T02:03:17ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2016-03-01610.3389/fonc.2016.00053180836DUBs, new members in the hypoxia signaling clUbAmelie S Schober0Amelie S Schober1Edurne eBerra2CIC bioGUNEUniversity of LiverpoolCIC bioGUNECellular protein homeostasis is tightly regulated by ubiquitination. Responsible for target protein ubiquitination is a class of enzymes, the so-called ubiquitin (Ub) E3-ligases. They are opposed to a second class of enzymes, called DeUBiquitinating enzymes (DUBs), which can remove polyubiquitin chains from their specific target proteins. The coaction of the two sets of enzymes allow the cell to adapt its overall protein content and the abundance of particular proteins to a variety of cellular and environmental stresses, including hypoxia. In recent years, DUBs have been highlighted to play major roles in many diseases, including cancer, both as tumor suppressors and oncogenes. Therefore, DUBs are emerging as promising targets for cancer-cell specific treatment. Here, we will review the current understanding of DUBs implicated in the control of hypoxia-inducible factor (HIF), the regulation of DUBs by hypoxia and the use of DUB-specific drugs to target tumor hypoxia signaling.http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00053/fullUbiquitinationCancerHIFDUBsProtein homeostasis |
| spellingShingle | Amelie S Schober Amelie S Schober Edurne eBerra DUBs, new members in the hypoxia signaling clUb Frontiers in Oncology Ubiquitination Cancer HIF DUBs Protein homeostasis |
| title | DUBs, new members in the hypoxia signaling clUb |
| title_full | DUBs, new members in the hypoxia signaling clUb |
| title_fullStr | DUBs, new members in the hypoxia signaling clUb |
| title_full_unstemmed | DUBs, new members in the hypoxia signaling clUb |
| title_short | DUBs, new members in the hypoxia signaling clUb |
| title_sort | dubs new members in the hypoxia signaling club |
| topic | Ubiquitination Cancer HIF DUBs Protein homeostasis |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00053/full |
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