Structure of Cyclosporine and Its Metabolites: Total Synthesis of Cyclosporine Metabolites Formed by Oxidation at Positions 4 and 9 of Cyclosporine. Preparation of Leucine-4-cyclosporine, (?-Hydroxy)-N-methyl-leucine-9-cyclosporine and Leucine-4-(?-hydroxy)-N-methyl-leucine-9-cyclosporine
The syntheses of the cyclosporine metabolites Leu-4-cyclosporine (AM4N), (?-OH)MeLeu-9-cyciosporine (AM9) and Leu-4-(?-OH)MeLeu-cyclosporine (AM4N9) were completed. Aspartic acid was used as starting material to prepare peptides containing (?-OH)MeLeu residues. The structure of metabolite...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
1992-07-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/2153 |