An improved analytical method for quantitation of nitrosamine impurities in ophthalmic solutions using liquid chromatography with tandem mass spectrometry
Nitrosamines are known to be a group of probable human carcinogens that are generally formed by the reaction of secondary and tertiary amines, amides, carbamates, or derivatives of urea with nitrite or other nitrogenous agents. Nitrites are common nitrosating impurities that have been reported in ma...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-11-01
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| Series: | Journal of Chromatography Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772391722000081 |