Prepulse inhibition predicts spatial working memory performance in the inbred Roman high- and low-avoidance rats and in genetically heterogeneous NIH-HS rats: relevance for studying pre-attentive and cognitive anomalies in schizophrenia

Prepulse inhibition predicts spatial working memory performance in the inbred Roman high- and low-avoidance rats and in genetically heterogeneous NIH-HS rats: relevance for studying pre-attentive and cognitive anomalies in schizophrenia

Animal models of schizophrenia-relevant symptoms are increasingly important for progress in our understanding of the neurobiological basis of the disorder and for discovering novel and more specific treatments. Prepulse inhibition (PPI) and working memory, which are impaired in schizophrenic patien...

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Bibliographic Details
Main Authors: Ignasi eOliveras, Cristobal eRío-Alamos, Toni eCañete, Gloria eBlázquez, Esther eMartínez-Membrives, Osvaldo eGiorgi, Maria G. eCorda, Adolf eTobeña, Alberto eFernandez-Teruel
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
prepulse inhibition
cognitive deficits
spatial working memory
Genetically heterogeneous rats
schizophrenia-relevant symptoms
schizophreniform rat model
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00213/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00213/full

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