Pancreatic mitochondrial complex I exhibits aberrant hyperactivity in diabetes

Pancreatic mitochondrial complex I exhibits aberrant hyperactivity in diabetes

It is well established that NADH/NAD+ redox balance is heavily perturbed in diabetes, and the NADH/NAD+ redox imbalance is a major source of oxidative stress in diabetic tissues. In mitochondria, complex I is the only site for NADH oxidation and NAD+ regeneration and is also a major site for product...

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Bibliographic Details
Main Authors: Jinzi Wu, Xiaoting Luo, Nopporn Thangthaeng, Nathalie Sumien, Zhenglan Chen, Margaret A. Rutledge, Siqun Jing, Michael J. Forster, Liang-Jun Yan
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
Diabetes
Pancreas
Complex I
Hyperactivity
Mitochondria
Redox imbalance
Streptozotocin
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580817301346

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http://www.sciencedirect.com/science/article/pii/S2405580817301346

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