TMPRSS2-ERG Gene Fusion Causing ERG Overexpression Precedes Chromosome Copy Number Changes in Prostate Carcinomas, Paired HGPIN Lesions

TMPRSS2-ERG Gene Fusion Causing ERG Overexpression Precedes Chromosome Copy Number Changes in Prostate Carcinomas, Paired HGPIN Lesions

TMPRSS2-ETS gene fusions have been found recurrently in prostate carcinomas, but not in the presumed precursor lesion, high-grade prostatic intraepithelial neoplasia (HGPIN). However, HGPIN lesions may share chromosomal changes with prostate cancer. To determine the relative order of genetic events...

Full description

Bibliographic Details
Main Authors: Nuno Cerveira, Franclim R. Ribeiro, Ana Peixoto, Vera Costa, Rui Henrique, Carmen Jerönimo, Manuel R. Teixeira
Format: Article
Language:English
Published: Elsevier 2006-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
TMPRSS2-ETS fusion oncogenes
prostate cancer
highgrade prostatic intraepithelial neoplasia
chromosomal changes
ERG
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800862

Internet

http://www.sciencedirect.com/science/article/pii/S1476558606800862

Similar Items