mTORC1/ERK1/2 Interplay Regulates Protein Synthesis and Survival in Acute Myeloid Leukemia Cell Lines

mTORC1/ERK1/2 Interplay Regulates Protein Synthesis and Survival in Acute Myeloid Leukemia Cell Lines

mTOR is constitutively activated in acute myeloid leukemia (AML) cells, as indicated by the phosphorylation of its substrates, 4EBP1 and P70S6K. Here, we found that quercetin (Q) and rapamycin (Rap) inhibited P70S6K phosphorylation, partially dephosphorylated 4EBP1, and activated ERK1/2 in U937 and...

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Bibliographic Details
Main Authors: Concetta Anna Germano, Giuseppe Clemente, Antonello Storniolo, Maria Anele Romeo, Elisabetta Ferretti, Mara Cirone, Livia Di Renzo
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Biology
Subjects:
AML
ERK1/2
mTORC1
AKT
quercetin
rapamycin
Online Access:https://www.mdpi.com/2079-7737/12/5/676

Internet

https://www.mdpi.com/2079-7737/12/5/676

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