Pharmacokinetics, tissue distribution, and plasma protein binding rate of curcumol in rats using liquid chromatography tandem mass spectrometry

Pharmacokinetics, tissue distribution, and plasma protein binding rate of curcumol in rats using liquid chromatography tandem mass spectrometry

Objective: Curcumol is one of the major active ingredients isolated from the traditional Chinese medicine Curcumae Rhizoma and is reported to exhibit various bioactivities, such as anti-tumor and anti-liver fibrosis effects. However, studies of curcumol pharmacokinetics and tissue distribution are c...

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Bibliographic Details
Main Authors: Zhaoxu Yang, Qingmei Sun, Sheng Wang, Bingbing Tang, Chenxing Yuan, Yue Wu, Jiabin Dai, Chen Yang, Lingkun Wang, Qian Zhou, Jincheng Wang, Qinjie Weng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
curcumol
UHPLC-MS/MS
pharmacokinetics
protein binding rate
tissue distribution
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1036732/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1036732/full

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