Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy

Drosophila expressing mutant human KCNT1 transgenes make an effective tool for targeted drug screening in a whole animal model of KCNT1-epilepsy

Abstract Mutations in the KCNT1 potassium channel cause severe forms of epilepsy which are poorly controlled with current treatments. In vitro studies have shown that KCNT1-epilepsy mutations are gain of function, significantly increasing K+ current amplitudes. To investigate if Drosophila can be us...

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Bibliographic Details
Main Authors: Rashid Hussain, Chiao Xin Lim, Zeeshan Shaukat, Anowarul Islam, Emily A. Caseley, Jonathan D. Lippiat, Grigori Y. Rychkov, Michael G. Ricos, Leanne M. Dibbens
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-53588-x

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https://doi.org/10.1038/s41598-024-53588-x

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