Glycation Interferes with the Expression of Sialyltransferases and Leads to Increased Polysialylation in Glioblastoma Cells

Glycation Interferes with the Expression of Sialyltransferases and Leads to Increased Polysialylation in Glioblastoma Cells

Glioblastoma (GBM) is a highly aggressive brain tumor that often utilizes aerobic glycolysis for energy production (Warburg effect), resulting in increased methylglyoxal (MGO) production. MGO, a reactive dicarbonyl compound, causes protein alterations and cellular dysfunction via glycation. In this...

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Bibliographic Details
Main Authors: Paola Schildhauer, Philipp Selke, Martin S. Staege, Anja Harder, Christian Scheller, Christian Strauss, Rüdiger Horstkorte, Maximilian Scheer, Sandra Leisz
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
glycation
glioblastoma
glioma
astrocytes
methylglyoxal
sialyltransferases
Online Access:https://www.mdpi.com/2073-4409/12/23/2758

Internet

https://www.mdpi.com/2073-4409/12/23/2758

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