Protein phosphorylation profiling using an in situ proximity ligation assay: phosphorylation of AURKA-elicited EGFR-Thr654 and EGFR-Ser1046 in lung cancer cells.

Protein phosphorylation profiling using an in situ proximity ligation assay: phosphorylation of AURKA-elicited EGFR-Thr654 and EGFR-Ser1046 in lung cancer cells.

The epidermal growth factor receptor (EGFR), which is up-regulated in lung cancer, involves the activation of mitogenic signals and triggers multiple signaling cascades. To dissect these EGFR cascades, we used 14 different phospho-EGFR antibodies to quantify protein phosphorylation using an in situ...

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Bibliographic Details
Main Authors: Tzu-Chi Chen, Yu-Wen Liu, Yei-Hsuan Huang, Yi-Chen Yeh, Teh-Ying Chou, Yu-Chung Wu, Chun-Chi Wu, Yi-Rong Chen, Hui-Chuan Cheng, Pei-Jung Lu, Jin-Mei Lai, Chi-Ying F Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3592865?pdf=render

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http://europepmc.org/articles/PMC3592865?pdf=render

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