Novel HDAC/Tubulin Dual Inhibitor: Design, Synthesis and Docking Studies of α-Phthalimido-Chalcone Hybrids as Potential Anticancer Agents with Apoptosis-Inducing Activity

Novel HDAC/Tubulin Dual Inhibitor: Design, Synthesis and Docking Studies of α-Phthalimido-Chalcone Hybrids as Potential Anticancer Agents with Apoptosis-Inducing Activity

Ahmed A E Mourad,1 Mai A E Mourad,2 Peter G Jones3 1Pharmacology and Toxicology Department, Faculty of Pharmacy, Port-Said University, Port-Said, Egypt; 2Medicinal Chemistry Department, Faculty of Pharmacy, Port-Said University, Port-Said, Egypt; 3Institute of Inorganic and Analytical Chemistry, Bra...

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Bibliographic Details
Main Authors: Mourad AAE, Mourad MAE, Jones PG
Format: Article
Language:English
Published: Dove Medical Press 2020-08-01
Series:Drug Design, Development and Therapy
Subjects:
chalcones
-phthalimido-
anticancer
cell cycle
histone deacetylase inhibitor
tubulin polymerase inhibitor
Online Access:https://www.dovepress.com/novel-hdactubulin-dual-inhibitor-design-synthesis-and-docking-studies--peer-reviewed-article-DDDT

Internet

https://www.dovepress.com/novel-hdactubulin-dual-inhibitor-design-synthesis-and-docking-studies--peer-reviewed-article-DDDT

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