Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation

Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation

IntroductionAutoinflammatory diseases are characterized by dysregulation of innate immune system leading to spontaneous sterile inflammation. One of the well-established animal models of this group of disorders is the mouse strain Pstpip2cmo. In this strain, the loss of adaptor protein PSTPIP2 leads...

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Bibliographic Details
Main Authors: Nataliia Pavliuchenko, Iris Duric, Jarmila Kralova, Matej Fabisik, Frantisek Spoutil, Jan Prochazka, Petr Kasparek, Jana Pokorna, Tereza Skopcova, Radislav Sedlacek, Tomas Brdicka
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
neutrophils
autoinflammation
chronic multifocal osteomyelitis
PSTPIP2
PEST-family phosphatases
SHIP1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1035226/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1035226/full

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