mTOR-inhibitors and post-transplant diabetes mellitus: a link still debated in kidney transplantation

mTOR-inhibitors and post-transplant diabetes mellitus: a link still debated in kidney transplantation

The mammalian target of rapamycin inhibitors (mTOR-Is, Sirolimus, and Everolimus) are immunosuppressive drugs widely employed in kidney transplantation. Their main mechanism of action includes the inhibition of a serine/threonine kinase with a pivotal role in cellular metabolism and in various eukar...

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Bibliographic Details
Main Authors: Simona Granata, Silvia Mercuri, Dario Troise, Loreto Gesualdo, Giovanni Stallone, Gianluigi Zaza
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Medicine
Subjects:
post-transplant diabetes mellitus
kidney transplantation
immunosuppressive drugs
allograft co-morbidities
mTOR-inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1168967/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1168967/full

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