Mathematical kinetic modelling followed by in vitro and in vivo assays reveal the bifunctional rice GTPCHII/DHBPS enzymes and demonstrate the key roles of OsRibA proteins in the vitamin B2 pathway

Mathematical kinetic modelling followed by in vitro and in vivo assays reveal the bifunctional rice GTPCHII/DHBPS enzymes and demonstrate the key roles of OsRibA proteins in the vitamin B2 pathway

Abstract Background Riboflavin is the precursor of several cofactors essential for normal physical and cognitive development, but only plants and some microorganisms can produce it. Humans thus rely on their dietary intake, which at a global level is mainly constituted by cereals (> 50%). Underst...

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Bibliographic Details
Main Authors: Maria Faustino, Tiago Lourenço, Simon Strobbe, Da Cao, André Fonseca, Isabel Rocha, Dominique Van Der Straeten, M. Margarida Oliveira
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Plant Biology
Subjects:
Biofortification
2,5-diamin-6-ribosylamino-4(3H)-pyrimidinone-5-phosphate
3,4-dihydroxy-2-butanone-4-phosphate
Limiting step
Oryza sativa
RibA
Online Access:https://doi.org/10.1186/s12870-024-04878-z

Internet

https://doi.org/10.1186/s12870-024-04878-z

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