Revisiting Supersaturation of a Biopharmaceutical Classification System IIB Drug: Evaluation via a Multi-Cup Dissolution Approach and Molecular Dynamic Simulation

Revisiting Supersaturation of a Biopharmaceutical Classification System IIB Drug: Evaluation via a Multi-Cup Dissolution Approach and Molecular Dynamic Simulation

As a subclass of the biopharmaceutical classification system (BCS) class II, basic drugs (BCS IIB) exhibit pH-dependent solubility and tend to generate supersaturation in the gastrointestinal tract, leading to less qualified in vitro–in vivo correlation (IVIVC). This study aims to develop a physiolo...

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Bibliographic Details
Main Authors: Yanxiong Gan, Yaxin Xu, Xue Zhang, Huiling Hu, Wenke Xiao, Zheng Yu, Tao Sun, Jinming Zhang, Chuanbiao Wen, Shichao Zheng
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Molecules
Subjects:
supersaturation
precipitation inhibitor
dissolution model
molecular dynamics
in vitro–in vivo correlation
Online Access:https://www.mdpi.com/1420-3049/28/19/6962

Internet

https://www.mdpi.com/1420-3049/28/19/6962

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