Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir

Selective resistance profiles emerging in patient-derived clinical isolates with cabotegravir, bictegravir, dolutegravir, and elvitegravir

Abstract Background Integrase strand transfer inhibitors (INSTIs) are recommended for first-line HIV therapy based on their relatively high genetic barrier to resistance. Although raltegravir (RAL) and elvitegravir (EVG) resistance profiles are well-characterized, resistance patterns for dolutegravi...

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Bibliographic Details
Main Authors: Maureen Oliveira, Ruxandra-Ilinca Ibanescu, Kaitlin Anstett, Thibault Mésplède, Jean-Pierre Routy, Marjorie A. Robbins, Bluma G. Brenner, the Montreal Primary HIV (PHI) Cohort Study Group
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Retrovirology
Subjects:
HIV-1
Integrase inhibitors
Antiretroviral drug resistance
Cell culture selections
Primary HIV infection isolates
HIV subtypes
Online Access:http://link.springer.com/article/10.1186/s12977-018-0440-3

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http://link.springer.com/article/10.1186/s12977-018-0440-3

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