Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation

Intracerebral overexpression of miR-669c is protective in mouse ischemic stroke model by targeting MyD88 and inducing alternative microglial/macrophage activation

Abstract Background Ischemic stroke is a devastating disease without a cure. The available treatments for ischemic stroke, thrombolysis by tissue plasminogen activator, and thrombectomy are suitable only to a fraction of patients and thus novel therapeutic approaches are urgently needed. The neuroin...

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Bibliographic Details
Main Authors: Natalia Kolosowska, Maria Gotkiewicz, Hiramani Dhungana, Luca Giudice, Rosalba Giugno, Daphne Box, Mikko T. Huuskonen, Paula Korhonen, Flavia Scoyni, Katja M. Kanninen, Seppo Ylä-Herttuala, Tiia A. Turunen, Mikko P. Turunen, Jari Koistinaho, Tarja Malm
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Neuroinflammation
Subjects:
Stroke
Neuroinflammation
MicroRNAs
Microglia/macrophage activation
Functional improvement
Online Access:http://link.springer.com/article/10.1186/s12974-020-01870-w

Internet

http://link.springer.com/article/10.1186/s12974-020-01870-w

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