Functional SNP allele discovery (fSNPd): an approach to find highly penetrant, environmental-triggered genotypes underlying complex human phenotypes

Functional SNP allele discovery (fSNPd): an approach to find highly penetrant, environmental-triggered genotypes underlying complex human phenotypes

Abstract Background Significant human diseases/phenotypes exist which require both an environmental trigger event and a genetic predisposition before the disease/phenotype emerges, e.g. Carbamazepine with the rare SNP allele of rs3909184 causing Stevens Johnson syndrome, and aminoglycosides with rs2...

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Bibliographic Details
Main Authors: Kaitlin Stouffer, Michael Nahorski, Pablo Moreno, Nivedita Sarveswaran, David Menon, Michael Lee, C. Geoffrey Woods
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Genomics
Subjects:
SNPs
Environmental trigger
Genetic predisposition
Phenotype
Online Access:http://link.springer.com/article/10.1186/s12864-017-4325-y

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http://link.springer.com/article/10.1186/s12864-017-4325-y

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