Botulinum Neurotoxin Light Chains Expressed by Defective Herpes Simplex Virus Type-1 Vectors Cleave SNARE Proteins and Inhibit CGRP Release in Rat Sensory Neurons

Botulinum Neurotoxin Light Chains Expressed by Defective Herpes Simplex Virus Type-1 Vectors Cleave SNARE Proteins and Inhibit CGRP Release in Rat Sensory Neurons

A set of herpes simplex virus type 1 (HSV-1) amplicon vectors expressing the light chains (LC) of botulinum neurotoxins (BoNT) A, B, C, D, E and F was constructed. Their properties have been assessed in primary cultures of rat embryonic dorsal root ganglia (DRG) neurons, and in organotypic cultures...

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Bibliographic Details
Main Authors: Charles Joussain, Olivier Le Coz, Andrey Pichugin, Peggy Marconi, Filip Lim, Mariaconcetta Sicurella, Andrea Salonia, Francesco Montorsi, Francisco Wandosell, Keith Foster, François Giuliano, Alberto L. Epstein, Alejandro Aranda Muñoz
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Toxins
Subjects:
HSV-1 amplicon vectors
transgenic botulinum neurotoxins
light chains
sensory neurons
DRG
SNARE proteins
Online Access:https://www.mdpi.com/2072-6651/11/2/123

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https://www.mdpi.com/2072-6651/11/2/123

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