Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of RUNX1-FPD

Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of RUNX1-FPD

RUNX1 familial platelet disorder (RUNX1-FPD) is a hematopoietic disorder caused by germline loss-of-function mutations in the RUNX1 gene and characterized by thrombocytopathy, thrombocytopenia, and an increased risk of developing hematologic malignancies, mostly of myeloid origin. Disease pathophysi...

Full description

Bibliographic Details
Main Authors: Martijn P. T. Ernst, Eline Pronk, Claire van Dijk, Paulina M. H. van Strien, Tim V. D. van Tienhoven, Michiel J. W. Wevers, Mathijs A. Sanders, Eric M. J. Bindels, Nancy A. Speck, Marc H. G. P. Raaijmakers
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000824

Internet

http://journals.lww.com/10.1097/HS9.0000000000000824

Similar Items