Exosomes derived from atorvastatin-modified bone marrow dendritic cells ameliorate experimental autoimmune myasthenia gravis by up-regulated levels of IDO/Treg and partly dependent on FasL/Fas pathway

Exosomes derived from atorvastatin-modified bone marrow dendritic cells ameliorate experimental autoimmune myasthenia gravis by up-regulated levels of IDO/Treg and partly dependent on FasL/Fas pathway

Abstract Background Previously, we have demonstrated that spleen-derived dendritic cells (DCs) modified with atorvastatin suppressed immune responses of experimental autoimmune myasthenia gravis (EAMG). However, the effects of exosomes derived from atorvastatin-modified bone marrow DCs (BMDCs) (stat...

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Bibliographic Details
Main Authors: Xiao-Li Li, Heng Li, Min Zhang, Hua Xu, Long-Tao Yue, Xin-Xin Zhang, Shan Wang, Cong-Cong Wang, Yan-Bin Li, Ying-Chun Dou, Rui-Sheng Duan
Format: Article
Language:English
Published: BMC 2016-01-01
Series:Journal of Neuroinflammation
Subjects:
Atorvastatin
Exosomes
Experimental autoimmune myasthenia gravis
IDO
FasL
Online Access:http://link.springer.com/article/10.1186/s12974-016-0475-0

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http://link.springer.com/article/10.1186/s12974-016-0475-0

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