Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice

Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice

Abstract HDAC inhibitors (HDACi) exert beneficial effects in mdx mice, by promoting endogenous regeneration; however, the cellular determinants of HDACi activity on dystrophic muscles have not been determined. We show that fibroadipogenic progenitors (FAP) influence the regeneration potential of sat...

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Detaylı Bibliyografya
Asıl Yazarlar: Chiara Mozzetta, Silvia Consalvi, Valentina Saccone, Matthew Tierney, Adamo Diamantini, Kathryn J. Mitchell, Giovanna Marazzi, Giovanna Borsellino, Luca Battistini, David Sassoon, Alessandra Sacco, Pier Lorenzo Puri
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Springer Nature 2013-03-01
Seri Bilgileri:EMBO Molecular Medicine
Konular:
fibroadipogenic progenitors
HDAC inhibitors
muscle regeneration
muscle stem cells
muscular dystrophy
Online Erişim:https://doi.org/10.1002/emmm.201202096

Internet

https://doi.org/10.1002/emmm.201202096

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