Stochastic gene expression and chromosome interactions in protecting the human active X from silencing by XIST
Mammals use X chromosome inactivation to compensate for the sex difference in numbers of X chromosomes. A relatively unexplored question is how the active X is protected from inactivation by its own XIST gene, the long non-coding RNA, which initiates silence of the inactive X. Previous studies of a...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Nucleus |
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| Online Access: | http://dx.doi.org/10.1080/19491034.2020.1850981 |