Self‐Reinforced Bimetallic Mito‐Jammer for Ca2+ Overload‐Mediated Cascade Mitochondrial Damage for Cancer Cuproptosis Sensitization

Self‐Reinforced Bimetallic Mito‐Jammer for Ca2+ Overload‐Mediated Cascade Mitochondrial Damage for Cancer Cuproptosis Sensitization

Abstract Overproduction of reactive oxygen species (ROS), metal ion accumulation, and tricarboxylic acid cycle collapse are crucial factors in mitochondria‐mediated cell death. However, the highly adaptive nature and damage‐repair capabilities of malignant tumors strongly limit the efficacy of treat...

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Bibliographic Details
Main Authors: Chier Du, Xun Guo, Xiaoling Qiu, Weixi Jiang, Xiaoting Wang, Hongjin An, Jingxue Wang, Yuanli Luo, Qianying Du, Ruoyao Wang, Chen Cheng, Yuan Guo, Hua Teng, Haitao Ran, Zhigang Wang, Pan Li, Zhiyi Zhou, Jianli Ren
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Advanced Science
Subjects:
Ca2+ overload
cascade mitochondria damage
chemodynamic therapy
cuproptosis
immunotherapy
Online Access:https://doi.org/10.1002/advs.202306031

Internet

https://doi.org/10.1002/advs.202306031

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