A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

Three-dimensional (3D) culture systems have fueled hopes to bring about the next generation of more physiologically relevant high-throughput screens (HTS). However, current protocols yield either complex but highly heterogeneous aggregates (‘organoids’) or 3D structures with less physiological relev...

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Bibliographic Details
Main Authors: Henrik Renner, Martha Grabos, Katharina J Becker, Theresa E Kagermeier, Jie Wu, Mandy Otto, Stefan Peischard, Dagmar Zeuschner, Yaroslav TsyTsyura, Paul Disse, Jürgen Klingauf, Sebastian A Leidel, Guiscard Seebohm, Hans R Schöler, Jan M Bruder
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
high throughput screening
automation
organoid
3D cell culture
midbrain
high content imaging
Online Access:https://elifesciences.org/articles/52904

Internet

https://elifesciences.org/articles/52904

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