Early cytoskeletal protein modifications precede overt structural degeneration in the DBA/2J mouse model of glaucoma

Early cytoskeletal protein modifications precede overt structural degeneration in the DBA/2J mouse model of glaucoma

Axonal transport deficits precede structural loss in glaucoma and other neurodegenerations. Impairments in structural support, including modified cytoskeletal proteins and microtubule-destabilizing elements, could be initiating factors in glaucoma pathogenesis. We investigated the time course of cha...

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Bibliographic Details
Main Authors: Gina Nicole Wilson, Matthew Alan Smith, Denise M Inman, Christine M Dengler-Crish, Samuel David Crish
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Neuroscience
Subjects:
Axonal Transport
Cytoskeleton
Glaucoma
Phosphorylation
Spectrin
amyloid-beta
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00494/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00494/full

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