Evaluation of the inhibition performance of pyrrole derivatives against CYP450 isoforms

Cytochrome P450 is a heme-containing superfamily accountable for the oxidation of various pharmacologically active drugs. The aim of this study was to conduct in silico and in vitro activity assessments of recently synthesized pyrrole-based compounds against three major CYP450 isoforms – CYP1A2, CYP...

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Bibliographic Details
Main Authors: Magdalena Kondeva-Burdina, Emilio Mateev, Ali Irfan, Hristina Kuteva, Maya Georgieva
Format: Article
Language:English
Published: Pensoft Publishers 2024-05-01
Series:Pharmacia
Online Access:https://pharmacia.pensoft.net/article/122067/download/pdf/