Capsaicin Is a Negative Allosteric Modulator of the 5-HT3 Receptor

Capsaicin Is a Negative Allosteric Modulator of the 5-HT3 Receptor

In this study, effects of capsaicin, an active ingredient of the capsicum plant, were investigated on human 5-hydroxytryptamine type 3 (5-HT3) receptors. Capsaicin reversibly inhibited serotonin (5-HT)-induced currents recorded by two-electrode voltage clamp method in Xenopus oocytes. The inhibition...

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Bibliographic Details
Main Authors: Eslam El Nebrisi, Tatiana Prytkova, Dietrich Ernst Lorke, Luke Howarth, Asma Hassan Alzaabi, Keun-Hang Susan Yang, Frank C. Howarth, Murat Oz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
capsaicin
5-HT3 receptor
Xenopus oocytes
HEK-293 cells
serotonin
allosteric modulator
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01274/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01274/full

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