Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis

Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis

Summary: Somatic copy number gains are pervasive across cancer types, yet their roles in oncogenesis are insufficiently evaluated. This inadequacy is partly due to copy gains spanning large chromosomal regions, obscuring causal loci. Here, we employed organoid modeling to evaluate candidate oncogeni...

Full description

Bibliographic Details
Main Authors: Ameen A. Salahudeen, Jose A. Seoane, Kanako Yuki, Amanda T. Mah, Amber R. Smith, Kevin Kolahi, Sean M. De la O, Daniel J. Hart, Jie Ding, Zhicheng Ma, Sammy A. Barkal, Navika D. Shukla, Chuck H. Zhang, Michael A. Cantrell, Arpit Batish, Tatsuya Usui, David E. Root, William C. Hahn, Christina Curtis, Calvin J. Kuo
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723013670

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723013670

Similar Items