Deletion of Interleukin-1β Converting Enzyme Alters Mouse Cardiac Structure and Function

Deletion of Interleukin-1β Converting Enzyme Alters Mouse Cardiac Structure and Function

Interleukin-1β converting enzyme (ICE, caspase-1) is a thiol protease that cleaves the pro-inflammatory cytokine precursors of IL-1β and IL-18 into active forms. Given the association between caspase-1 and cardiovascular pathology, we analyzed the hearts of ICE knockout (ICE KO) mice to test the hyp...

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Bibliographic Details
Main Authors: Gohar Azhar, Koichiro Nagano, Pankaj Patyal, Xiaomin Zhang, Ambika Verma, Jeanne Y. Wei
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Biology
Subjects:
caspase-1
cardiac hypertrophy
oxidative stress
MAPK
apoptosis
Online Access:https://www.mdpi.com/2079-7737/13/3/172

Internet

https://www.mdpi.com/2079-7737/13/3/172

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