Targeting Mitochondrial COX-2 Enhances Chemosensitivity via Drp1-Dependent Remodeling of Mitochondrial Dynamics in Hepatocellular Carcinoma

Targeting Mitochondrial COX-2 Enhances Chemosensitivity via Drp1-Dependent Remodeling of Mitochondrial Dynamics in Hepatocellular Carcinoma

Mitochondria are highly dynamic organelles and undergo constant fission and fusion, which are both essential for the maintenance of cell physiological functions. Dysregulation of dynamin-related protein 1 (Drp1)-dependent mitochondrial dynamics is associated with tumorigenesis and the chemotherapeut...

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Bibliographic Details
Main Authors: Lin Che, Jia-Shen Wu, Ze-Bang Du, Yu-Qiao He, Lei Yang, Jin-Xian Lin, Zhao Lei, Xiao-Xuan Chen, Dong-Bei Guo, Wen-Gang Li, Yu-Chun Lin, Zhong-Ning Lin
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cancers
Subjects:
mitochondrial cyclooxygenase-2
dynamin-related protein 1
mitochondrial dynamics
sirtuin 3
apoptosis
hepatocellular carcinoma
Online Access:https://www.mdpi.com/2072-6694/14/3/821

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https://www.mdpi.com/2072-6694/14/3/821

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