Culturing pancreatic islets in microfluidic flow enhances morphology of the associated endothelial cells.

Culturing pancreatic islets in microfluidic flow enhances morphology of the associated endothelial cells.

Pancreatic islets are heavily vascularized in vivo with each insulin secreting beta-cell associated with at least one endothelial cell (EC). This structure is maintained immediately post-isolation; however, in culture the ECs slowly deteriorate, losing density and branched morphology. We postulate t...

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Bibliographic Details
Main Authors: Krishana S Sankar, Brenda J Green, Alana R Crocker, Jocelyne E Verity, Svetlana M Altamentova, Jonathan V Rocheleau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3178551?pdf=render

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http://europepmc.org/articles/PMC3178551?pdf=render

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