Single-cell multi-omics analysis identifies SPP1+ macrophages as key drivers of ferroptosis-mediated fibrosis in ligamentum flavum hypertrophy

Single-cell multi-omics analysis identifies SPP1+ macrophages as key drivers of ferroptosis-mediated fibrosis in ligamentum flavum hypertrophy

Abstract Background Ligamentum flavum hypertrophy (LFH) is a primary contributor to lumbar spinal stenosis. However, a thorough understanding of the cellular and molecular mechanisms driving LFH fibrotic progression remains incomplete. Methods Single-cell RNA sequencing (scRNA-seq) was performed to...

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Bibliographic Details
Main Authors: Chengshuo Fei, Yanlin Chen, Ruiqian Tan, Xinxing Yang, Guanda Wu, Chenglong Li, Jiawei Shi, Shiyong Le, Wenjie Yang, Jiajia Xu, Liang Wang, Zhongmin Zhang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Biomarker Research
Subjects:
Ligamentum flavum hypertrophy
Fibrosis
Ferroptosis
Single-cell RNA sequencing
Multi-omics analysis
Macrophages.
Online Access:https://doi.org/10.1186/s40364-025-00746-6

Internet

https://doi.org/10.1186/s40364-025-00746-6

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