Oroxylin a Inhibits the Protection of Bone Marrow Microenvironment on CML Cells Through CXCL12/CXCR4/P-gp Signaling Pathway

Oroxylin a Inhibits the Protection of Bone Marrow Microenvironment on CML Cells Through CXCL12/CXCR4/P-gp Signaling Pathway

Imatinib (IM) resistance could have significant impact on the survival time of the CML-patients treated with IM. Previous studies have shown that the protective effects of the bone marrow stroma cells (BMSCs) on CML cells are achieved by the secretion of CXCL12. The aim of this study was to investig...

Full description

Bibliographic Details
Main Authors: Hanbo Cao, Wenjun Li, Yizhou Zhou, Renxiang Tan, Yue Yang, You Zhou, Qinglong Guo, Li Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Oncology
Subjects:
bone marrow environment
CXCL12/CXCR4
oroxylin A
Imatinib (IM)
β-catenin/P-gp
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00188/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00188/full

Similar Items