Engineering Escherichia coli for high-yielding 2,5-Dimethylpyrazine synthesis from L-Threonine by reconstructing metabolic pathways and enhancing cofactors regeneration

Engineering Escherichia coli for high-yielding 2,5-Dimethylpyrazine synthesis from L-Threonine by reconstructing metabolic pathways and enhancing cofactors regeneration

Abstract 2,5-Dimethylpyrazine (2,5-DMP) is important pharmaceutical raw material and food flavoring agent. Recently, engineering microbes to produce 2,5-DMP has become an attractive alternative to chemical synthesis approach. In this study, metabolic engineering strategies were used to optimize the...

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Bibliographic Details
Main Authors: Xin-Xin Liu, Yao Wang, Jian-Hui Zhang, Yun-Feng Lu, Zi-Xing Dong, Chao Yue, Xian-Qing Huang, Si-Pu Zhang, Dan-Dan Li, Lun-Guang Yao, Cun-Duo Tang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Biotechnology for Biofuels and Bioproducts
Subjects:
2,5-dimethylpyrazine
Metabolic engineering
Microbial cell factories
Aminoacetone oxidase
Threonine transporter
Whole-cell catalysis
Online Access:https://doi.org/10.1186/s13068-024-02487-4

Internet

https://doi.org/10.1186/s13068-024-02487-4

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