In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection

In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection

Abstract The strategies deployed by antibiotic‐resistant bacteria to counteract host defences are poorly understood. Here, we elucidate a novel host–pathogen interaction resulting in skewing lung macrophage polarisation by the human pathogen Klebsiella pneumoniae. We identify interstitial macrophage...

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Bibliographic Details
Main Authors: Amy Dumigan, Oisin Cappa, Brenda Morris, Joana Sá Pessoa, Ricardo Calderon‐Gonzalez, Grant Mills, Rebecca Lancaster, David Simpson, Adrien Kissenpfennig, Jose A Bengoechea
Format: Article
Language:English
Published: Springer Nature 2022-12-01
Series:EMBO Molecular Medicine
Subjects:
IL10
Klebsiella
macrophage polarisation
STAT6
type I IFN
Online Access:https://doi.org/10.15252/emmm.202216888

Internet

https://doi.org/10.15252/emmm.202216888

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