Metformin inhibits glutaminase activity and protects against hepatic encephalopathy.

Metformin inhibits glutaminase activity and protects against hepatic encephalopathy.

AIM: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients. To analyze the impact of metformin on glutaminase activity and ammonia production in vitro. METHODS: Eighty-two cirrhotic patients with type 2...

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Main Authors: Javier Ampuero, Isidora Ranchal, David Nuñez, María del Mar Díaz-Herrero, Marta Maraver, José Antonio del Campo, Ángela Rojas, Inés Camacho, Blanca Figueruela, Juan D Bautista, Manuel Romero-Gómez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3499552?pdf=render

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http://europepmc.org/articles/PMC3499552?pdf=render

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