Cell Fate following Irradiation of MDA-MB-231 and MCF-7 Breast Cancer Cells Pre-Exposed to the Tetrahydroisoquinoline Sulfamate Microtubule Disruptor STX3451

Cell Fate following Irradiation of MDA-MB-231 and MCF-7 Breast Cancer Cells Pre-Exposed to the Tetrahydroisoquinoline Sulfamate Microtubule Disruptor STX3451

A tetrahydroisoquinoline (THIQ) core is able to mimic the A and B rings of 2-methoxyestradiol (2ME2), an endogenous estrogen metabolite that demonstrates promising anticancer properties primarily by disrupting microtubule dynamic instability parameters, but has very poor pharmaceutical properties th...

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Bibliographic Details
Main Authors: Scott D. Hargrave, Anna M. Joubert, Barry V. L. Potter, Wolfgang Dohle, Sumari Marais, Anne E. Mercier
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
cancer
2-methoxyestradiol
tetrahydroisoquinoline analog (STX3451)
radiosensitization
reactive oxygen species
apoptosis
Online Access:https://www.mdpi.com/1420-3049/27/12/3819

Internet

https://www.mdpi.com/1420-3049/27/12/3819

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