A single-center study of bone mineral density in adult patients with severe hemophilia A in correlation with markers of bone metabolism

Introduction: Osteopenia and osteoporosis are well-known hemophilia A comorbidities. The pathogenesis of bone turnover alteration resulting in reduced bone mass includes impaired osteoblastic differentiation and disinhibition of RANKL-induced osteoclastogenesis as a result of a low FVIII level.Aim:...

Full description

Bibliographic Details
Main Authors: Hristina A. Ivanova, Zhanet Grudeva-Popova, Tanya Deneva, Silvia Tsvetkova, Nonka Mateva
Format: Article
Language:English
Published: Pensoft Publishers 2023-02-01
Series:Folia Medica
Subjects:
Online Access:https://foliamedica.bg/article/75414/download/pdf/