It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods

It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods

Among cyclic nucleotide phosphodiesterases (PDEs), PDE6 is unique in serving as an effector enzyme in G protein-coupled signal transduction. In retinal rods and cones, PDE6 is membrane-bound and activated to hydrolyse its substrate, cGMP, by binding of two active G protein α-subunits (Gα*). To inves...

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Bibliographic Details
Main Authors: Bilal M. Qureshi, Elmar Behrmann, Johannes Schöneberg, Justus Loerke, Jörg Bürger, Thorsten Mielke, Jan Giesebrecht, Frank Noé, Trevor D. Lamb, Klaus Peter Hofmann, Christian M. T. Spahn, Martin Heck
Format: Article
Language:English
Published: The Royal Society 2018-08-01
Series:Open Biology
Subjects:
pde6
visual signal transduction
coincidence switch
density switch
noise filtering
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180075

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180075

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