It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods
Among cyclic nucleotide phosphodiesterases (PDEs), PDE6 is unique in serving as an effector enzyme in G protein-coupled signal transduction. In retinal rods and cones, PDE6 is membrane-bound and activated to hydrolyse its substrate, cGMP, by binding of two active G protein α-subunits (Gα*). To inves...
| Autori principali: | , , , , , , , , , , , |
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| Natura: | Articolo |
| Lingua: | English |
| Pubblicazione: |
The Royal Society
2018-08-01
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| Serie: | Open Biology |
| Soggetti: | |
| Accesso online: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.180075 |