Cyproterone Acetate Mediates IRE1α Signaling Pathway to Alleviate Pyroptosis of Ovarian Granulosa Cells Induced by Hyperandrogen

Objective: Hyperandrogenemia (HA) is the main pathophysiological change that takes place in polycystic ovary syndrome (PCOS). Cyproterone acetate (CYA) is a drug commonly used to reduce androgen in patients with PCOS. Long-term and continuous exposure to HA can cause ovarian granulosa cells (GCs), p...

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Bibliographic Details
Main Authors: Yan Zhang, Xianguo Xie, Yabo Ma, Changzheng Du, Yuan Jiao, Guoliang Xia, Jinrui Xu, Yi Yang
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biology
Subjects:
Online Access:https://www.mdpi.com/2079-7737/11/12/1761