Quantification of the trans-synaptic partners neurexin-neuroligin in CSF of neurodegenerative diseases by parallel reaction monitoring mass spectrometry

Quantification of the trans-synaptic partners neurexin-neuroligin in CSF of neurodegenerative diseases by parallel reaction monitoring mass spectrometry

Summary: Background: Synaptic proteins are increasingly studied as biomarkers for synaptic dysfunction and loss, which are early and central events in Alzheimer's disease (AD) and strongly correlate with the degree of cognitive decline. In this study, we specifically investigated the synaptic...

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Bibliographic Details
Main Authors: Elena Camporesi, Johanna Nilsson, Agathe Vrillon, Emmanuel Cognat, Claire Hourregue, Henrik Zetterberg, Kaj Blennow, Bruno Becker, Ann Brinkmalm, Claire Paquet, Gunnar Brinkmalm
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:EBioMedicine
Subjects:
synaptic proteins
neurexins
neuroligins
Alzheimer's disease
biomarkers
mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421005879

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http://www.sciencedirect.com/science/article/pii/S2352396421005879

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