Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes

Integration of genetic, transcriptomic, and clinical data provides insight into 16p11.2 and 22q11.2 CNV genes

Abstract Background Deletions and duplications of the multigenic 16p11.2 and 22q11.2 copy number variant (CNV) regions are associated with brain-related disorders including schizophrenia, intellectual disability, obesity, bipolar disorder, and autism spectrum disorder (ASD). The contribution of indi...

Full description

Bibliographic Details
Main Authors: Mikhail Vysotskiy, Xue Zhong, Tyne W. Miller-Fleming, Dan Zhou, Autism Working Group of the Psychiatric Genomics Consortium^, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium^, Schizophrenia Working Group of the Psychiatric Genomics Consortium^, Nancy J. Cox, Lauren A. Weiss
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Genome Medicine
Subjects:
Copy number variants
Transcriptome imputation
Electronic health records
Psychiatric traits
Phenome-wide association studies
Online Access:https://doi.org/10.1186/s13073-021-00972-1

Internet

https://doi.org/10.1186/s13073-021-00972-1

Similar Items